PDRN Skin Booster - Polynucleotide Salmon DNA
MESO SECRET® HYDRO PDRN is a 2.5 ml prefilled syringe skin booster built on polynucleotide — Sodium DNA (PDRN) — with Sodium Hyaluronate and Niacinamide alongside it. It is supplied as one sealed syringe per box for the areas that show age first: the forehead, crow's feet, smoker lines, smiles lines, the neck, the hands and the décolletage.
Why HYDRO PDRN
Three named actives, one sealed syringe, and nothing on the label left unnamed.
- Polynucleotide at the core — Sodium DNA (PDRN), the salmon-derived polynucleotide the whole formula is built around.
- Sodium Hyaluronate alongside it — the sodium salt of hyaluronic acid, and the carrier that gives the fill its smooth, even draw.
- Niacinamide to round it out — a third named active, so this is a complete three-part formula rather than a polynucleotide on its own.
What arrives in the box
Every unit leaves the packing line sealed, and reaches you the same way.
- One sealed prefilled syringe — a 2.5 ml fill held in a blister tray inside the carton, so the barrel touches nothing until you open it.
- A graduated barrel, 0.5 to 2.5 ml — clear markings so you can follow how much has been drawn and keep the dose even across areas.
- A screw-on tip cap — it seals the syringe outlet until the moment you begin.
- Box quantities that scale — start with one box to see how the routine fits, move up once you know it does.
Where it is used
HYDRO PDRN is made for the places where skin thins and creases first — seven areas in total.
- The upper face — the forehead, with crow's feet around the eye named on their own.
- The mid and lower face — smoker lines around the mouth, and smiles lines.
- Below the jawline — the neck, the hands, and the décolletage.
Frequently asked questions
What exactly is PDRN?
PDRN stands for polydeoxyribonucleotide, a fragment of a polynucleotide chain. In HYDRO PDRN it is declared on the pack as Sodium DNA (PDRN), and the listing describes it as salmon-derived. It is the substance the formula is built around, and the term most buyers search for it by.
Where can it be used?
Seven areas are named: the forehead, crow's feet, smoker lines, smiles lines, the neck, the hands and the décolletage. Each of those areas has its own skin thickness and its own movement, so the amount that suits one is not automatically right for the next.
What is the difference between PDRN and PN?
Both names describe polynucleotides, and the two are used loosely across the category, which is why they are so often confused. What actually separates one product from another is the concentration, the molecule size and how the raw material was sourced — the three things worth asking about before you settle on a product.
What should I expect after using it?
The area may look and feel flushed for a short while, which is normal once product has been placed into the skin. Feedback ranges from barely noticeable to a few tender days, and the difference usually follows volume, area and technique rather than the product itself. Fine results build across sessions rather than arriving after the first one. If you have an active skin condition or a history of poor healing in the area, take qualified advice before you start.
What it pairs with
Meso Secret Collagen Booster Same format, different active 
100% Pure HA Serum Plain hyaluronate, no PDRN See the full range on the skinbooster collection page.
